Ac. Abadiamolina et al., IMMUNE PHENOTYPE AND CYTOTOXIC ACTIVITY OF LYMPHOCYTES FROM HUMAN TERM DECIDUA AGAINST TROPHOBLAST, Journal of reproductive immunology, 31(1-2), 1996, pp. 109-123
Flow cytometric data were used to compare the phenotype of term decidu
al lymphocytes and peripheral blood lymphocytes. Unlike peripheral blo
od lymphocytes, a significant percentage of CD3(+), CD4(+), CD8(+) and
CD16(+) term decidual lymphocyte populations expressed the CD69 activ
ation marker. The relative proportions,of CD38 in CD3(+), CD4(+) and C
D8(+) populations were more than twice as large in term decidual lymph
ocytes as in peripheral blood lymphocytes. As reported for early-decid
ual lymphocytes, the expression of CD38 and CD69 by term decidual lymp
hocytes suggests that these cells are also regionally activated. Howev
er, term decidual lymphocytes showed no spontaneous cytotoxicity again
st normal trophoblast or its tumoral counterpart, JEG cells. After sti
mulation with interleukin-2, these lymphocytes became cytotoxic, as di
d peripheral blood lymphocytes. The relevance of this latter result to
the immune control of the physiological and pathological invasion of
the decidua by the trophoblast is discussed.