SOME ADDITIONAL RESULTS ABOUT POLYMORPHISMS IN MODELS OF AN ADDITIVE QUANTITATIVE TRAIT UNDER STABILIZING SELECTION

Authors
Citation
A. Gimelfarb, SOME ADDITIONAL RESULTS ABOUT POLYMORPHISMS IN MODELS OF AN ADDITIVE QUANTITATIVE TRAIT UNDER STABILIZING SELECTION, Journal of mathematical biology, 35(1), 1996, pp. 88-96
Citations number
13
Categorie Soggetti
Mathematical Methods, Biology & Medicine","Biology Miscellaneous","Mathematics, Miscellaneous
ISSN journal
03036812
Volume
35
Issue
1
Year of publication
1996
Pages
88 - 96
Database
ISI
SICI code
0303-6812(1996)35:1<88:SARAPI>2.0.ZU;2-O
Abstract
The existence of two stable? symmetric (allelic frequency 0.5 in each locus) polymorphic states is demonstrated for a two-locus model of an additive quantitative trait under strong Gaussian selection. Linkage d isequilibrium at one of the states is negative whereas it is positive at the other state. For a three-locus model, it is shown that in order to maintain a stable polymorphism in all three loci, selection must b e sufficiently but not excessively strong relative to recombination. A lso, positive linkage disequilibrium can be maintained in a three-locu s model under stabilizing selection that is not very strong.