We measured levels of hemoglobin F in 83 newborns and compared them wi
th risk factors for sudden infant death syndrome (SIDS). Results were
consistent with previous studies that found higher levels of hemoglobi
n F in newborns with shorter gestations and lower birth weights. Male
newborns had higher levels of hemoglobin F than did female newborns, b
ut the difference was not statistically significant, All ethnic groups
except Asians had higher levels of hemoglobin F at birth than did Cau
casians. Age of the ;mother during pregnancy was not related to the le
vel of hemoglobin F in the newborn. We noted statistically significant
differences in the percentage of hemoglobin F among newborns from smo
king vs nonsmoking mothers. Overall, we found that factors associated
with high risk for SIDS are similar to factors leading to higher level
s of hemoglobin F at birth.