VLA HI observations of the dwarf irregular galaxy NGC 2188 show that t
he gas and stars have spatial distributions which are substantially di
fferent. One end of the optical disk is strongly gas deficient, while
neutral gas extends into the halo over distances of more than 2 kpc fr
om the midplane. This and the peculiar velocity field suggest that NGC
2188 is a perturbed system, although it is not obviously an interacti
ng galaxy. In addition, NGC 2188 is remarkable for its interstellar di
sk-halo connection. An Ha image of NGC 2188 shows the presence of spec
tacular features of ionized gas extending from a large star-forming co
mplex up to 500 pc into the halo. Also, peculiar HI filaments and at l
east one superbubble are present in NGC 2188.