From the sponge, Ircinia dendroides, collected in Indonesia we isolate
d a new cyclic hexapeptide, waiakeamide (1). Its structure, consisting
of three proline residues, two methionine sulfoxides, and one thiazol
ylphenylalanine, was elucidated by spectral analysis and chemical degr
adation. Isolation and structural elucidation of waiakeamide is descri
bed.