PREISCHEMIC BOLUS APPLICATION OF PIROXIMONE STUDIED ON THE ISOLATED RABBIT HEART - A 2ND LOOK INCLUDING BIOCHEMICAL DATA

in a randomized prospective experimental study on 48 adult white Elco rabbits biochemical and rhythmic changes after bolus administration of the phosphodiesterase inhibitor piroximone were investigated using a working heart model, The treatment group (n = 21) intravenously receiv ed 1 mg/kg of piroximone 15 min before thoracotomy, Twenty-three untre ated hearts served as the control group, From 6 hearts of each group m yocardial biopsies were taken before ischemia, 4 (2/2) hearts were exc luded, Hemodynamic results of a previous study with an identical proto col were reanalyzed; a biochemical analysis of myocardial high-energy phosphates was investigated after 60 min of global ischemia and at the end of the experiments after 45 min of reperfusion, Already prior to ischemia, in the treatment group depletion of high-energy phosphates w as detected, After 60 min of ischemia during early reperfusion in the treatment group ATP and creatine phosphate depletion became even more evident and increased until the end of the experiments, The incidence of reperfusion-induced arrhythmias was significantly lower in the trea tment group, Consequently these results and the hemodynamic results of prior studies indicate a possible positive effect of piroximone durin g the early reperfusion period by optimizing hemodynamics and arrhythm ias.