B. Podesser et al., PREISCHEMIC BOLUS APPLICATION OF PIROXIMONE STUDIED ON THE ISOLATED RABBIT HEART - A 2ND LOOK INCLUDING BIOCHEMICAL DATA, European surgical research, 28(5), 1996, pp. 388-394
in a randomized prospective experimental study on 48 adult white Elco
rabbits biochemical and rhythmic changes after bolus administration of
the phosphodiesterase inhibitor piroximone were investigated using a
working heart model, The treatment group (n = 21) intravenously receiv
ed 1 mg/kg of piroximone 15 min before thoracotomy, Twenty-three untre
ated hearts served as the control group, From 6 hearts of each group m
yocardial biopsies were taken before ischemia, 4 (2/2) hearts were exc
luded, Hemodynamic results of a previous study with an identical proto
col were reanalyzed; a biochemical analysis of myocardial high-energy
phosphates was investigated after 60 min of global ischemia and at the
end of the experiments after 45 min of reperfusion, Already prior to
ischemia, in the treatment group depletion of high-energy phosphates w
as detected, After 60 min of ischemia during early reperfusion in the
treatment group ATP and creatine phosphate depletion became even more
evident and increased until the end of the experiments, The incidence
of reperfusion-induced arrhythmias was significantly lower in the trea
tment group, Consequently these results and the hemodynamic results of
prior studies indicate a possible positive effect of piroximone durin
g the early reperfusion period by optimizing hemodynamics and arrhythm
ias.