C. Boss et R. Keese, SYNTHESIS AND STRUCTURE OF FUNCTIONALIZED CYCLODODECADIYNES AND CYCLODODECADIENES, Helvetica Chimica Acta, 79(8), 1996, pp. 2164-2175
The cyclododecadiynes 3b-d, 8b-d, and 10b-c with functionalities in tw
o propargylic positions, as well as the monofunctionalized diyne 13b h
ave been prepared from simple open-chain building blocks. In the DMPU
(= N,N'-dimethylpropyleneurea)-assisted ring-closing alkylation of 1,7
-diynes, the twelve-membered ring compounds have been prepared in yiel
ds of 16-55%. The preparation of the diene-diyne 15 and the cyclododec
a-5,11-diyne-1,4-dione 18 are described.