Scope: This review summarizes the main issues discussed during Track D
, which examined the societal impact of HIV/AIDS, and responses to the
epidemic by individuals, families, communities and societies worldwid
e. Micro- and macrolevel issues addressed included the development, im
plementation and evaluation of programmes for prevention and care; pol
icy development and implementation; structural issues such as the impa
ct of gender relations, development and migration on the development o
f the epidemic; and the social and economic impact of HIV/AIDS on affe
cted societies and communities. Recurrent themes: Presentations provid
ed strong evidence that peer-led, community-based programmes offer par
ticularly effective ways of working, and that participatory research i
nvolving affected communities provides useful results for the design a
nd evaluation of programmes and policies. This is the case across sett
ings, issues, populations and countries. Future directions: Emerging n
eeds include how best to ensure sustainability of national and interna
tional responses, how best to scale up successful interventions for wi
der reach, and how best to work with systematically marginalized, negl
ected groups and populations. Research priorities include the characte
rization of the multiple determinants of HIV-related vulnerability, an
d the evaluation of interventions that take these complex determinants
as their starting point. A more coherent and strategic response requi
res less separation between the different constituencies involved in A
IDS work, and the more sustained involvement of people living with HIV
/AIDS themselves.