MEMORY-ENHANCING EFFECTS OF BENZODIAZEPINES IN MICE

In the present study, post-trial effects of clonazepam and diazepam on inhibitory avoidance learning under two different experimental condit ions (i.e., 0.25 or 0.75 mA footshock) have been investigated. Both cl onazepam (0.5 mg/kg) and diazepam (2 and 8 mg/kg) enhanced retention w hen administered immediately after the 0.25 mA footshock applied durin g training of the inhibitory avoidance task. In contrast, clonazepam a nd diazepam proved ineffective after the 0.75 mA footshock. The result s suggest a post-training memory enhancing effect of clonazepam and di azepam depending on the experimental conditions.