Laryngeal papillomotasis recurred in 2 patients after 44 and 47 years
of remission. The recurrence of papillomatosis after such lengthy peri
ods of remission underscores the fact that, while surgical treatment o
f laryngeal papillomatosis may maintain the airway and voice, and in s
ome cases control clinically overt disease, it does not address the su
bclinical mucosal human papillomavirus infection that may lead to recu
rrence many years after surgery.