Objective: To compare the effects of expiratory muscle training and sh
am training on respiratory muscle strength in patients with multiple s
clerosis (MS). Design: A randomized control trial; subjects were rando
mly assigned to either expiratory muscle training or sham training. Se
tting: Training and measurement of respiratory muscle pressures were c
onducted in patients' homes. Weekly home visits were conducted to assu
re compliance with the training protocols and to obtain measurements,
Patients: Twenty subjects with clinically definite MS and decreased ex
piratory muscle strength entered the study; 10 subjects completed 3 mo
nths of expiratory training using a threshold training device and 5 su
bjects completed 3 months of sham training using the same device but w
ithout an expiratory training threshold load, Measurement: Respiratory
muscle strength was assessed at baseline and after 1, 2, and 3 months
of training; maximal inspiratory and expiratory pressures were used a
s measures of respiratory muscle strength. Results: There was a signif
icant increase in expiratory muscle strength after 3 months of trainin
g when the expiratory training group was compared to the sham group (p
= .003); no significant change in inspiratory muscle strength was obs
erved. Conclusions: The results of this pilot study suggest that the s
trength of the expiratory muscles of persons with MS can be increased
through respiratory muscle training targeted to the expiratory muscles
. Further research is indicated to determine if increasing the strengt
h of the expiratory muscles in MS has an effect on clinical outcomes i
n this patient population. (C) 1996 by the American Congress of Rehabi
litation Medicine and the American Academy of Physical Medicine and Re
habilitation