UTILIZATION OF AUTOLOGOUS CELL PRECURSORS OF HEMATOPOIESIS FROM PERIPHERAL-BLOOD FOR TRANSPLANTATION IN PATIENTS WITH HEMATOLOGICAL AND SOLID MALIGNANCIES AFTER HIGH-DOSE CHEMOTHERAPY

Citation
Vv. Ptushkin et al., UTILIZATION OF AUTOLOGOUS CELL PRECURSORS OF HEMATOPOIESIS FROM PERIPHERAL-BLOOD FOR TRANSPLANTATION IN PATIENTS WITH HEMATOLOGICAL AND SOLID MALIGNANCIES AFTER HIGH-DOSE CHEMOTHERAPY, Gematologia i transfuziologia, 41(1), 1996, pp. 9-13
Citations number
21
Categorie Soggetti
Hematology
ISSN journal
02345730
Volume
41
Issue
1
Year of publication
1996
Pages
9 - 13
Database
ISI
SICI code
0234-5730(1996)41:1<9:UOACPO>2.0.ZU;2-N
Abstract
Peripheral mononuclears under normal hemopoiesis and after chemotherap y or/and cytokins were isolated on blood cell separator and cryopreser ved. The cells from 22 patients with differrent hematological and soli d malignancies were examined. Mononuclears with high content of hemopo iesis precursors may be collected rapidly after stimulation. Fast and persistent recovery of hemopoiesis in transplantation of this material after superhigh-dose chemotherapy of prognostically unfavourable pati ents is demonstrated. Cytokins (granulocytic and granulocytic-macropha gal growth factors) promoted fast and reliable production of sufficien t quantities of peripheral blood hemopoiesis cells precursors.