UTILIZATION OF AUTOLOGOUS CELL PRECURSORS OF HEMATOPOIESIS FROM PERIPHERAL-BLOOD FOR TRANSPLANTATION IN PATIENTS WITH HEMATOLOGICAL AND SOLID MALIGNANCIES AFTER HIGH-DOSE CHEMOTHERAPY

Peripheral mononuclears under normal hemopoiesis and after chemotherap y or/and cytokins were isolated on blood cell separator and cryopreser ved. The cells from 22 patients with differrent hematological and soli d malignancies were examined. Mononuclears with high content of hemopo iesis precursors may be collected rapidly after stimulation. Fast and persistent recovery of hemopoiesis in transplantation of this material after superhigh-dose chemotherapy of prognostically unfavourable pati ents is demonstrated. Cytokins (granulocytic and granulocytic-macropha gal growth factors) promoted fast and reliable production of sufficien t quantities of peripheral blood hemopoiesis cells precursors.