MORPHOLOGICAL STRUCTURAL CHARACTERISTICS OF HEMATOPOIETIC MICROENVIRONMENT IN PATIENTS WITH MULTIPLE-MYELOMA

The authors' investigations found plasmocytic infiltration of bone mar row and marked resorption of bone tissue in patients with multiple mye loma (MM). Instead of the expected reduction in bone marrow volume the latter slightly increased. MM patients have significantly higher quan tity of endosteal stromal cells, accumulations of osteoblastic cellula r elements considered as initial osteogenesis. A close correlation was revealed between bone tissue volume, number of erythroid elements in bone marrow and red cell count in peripheral blood. Volume of fatty ti ssues in MM patients is low. MM patients demonstrate pronounced morpho functional disturbances in hemopoietic microenvironment of bone marrow .