EFFECTS OF THE COMPONENTS OF VIRUS-CONTAI NING ALLANTOIC FLUID ON THESTABILITY OF INFLUENZA-VIRUS UPON STORAGE

Effects of allantoic fluid fractions (isolated by sedimentation and ge l chromatography) on inactivation of influenza virus and lipid peroxid ation in viral envelopes and phospholipid liposomes indicate the prese nce of both components with prooxidant effects enhancing inactivation and of endogenous antioxidants stabilizing the viral activity. The hyp othesized ''lipid'' mechanism of inactivation (suggesting activation o f lipid peroxidation in viral envelopes followed by inactivation of vi ral nucleoprotein) permits a satisfactory interpretation of viral mate rial inactivation.