THE EFFICACY OF INTERFERON INDUCERS RIDOS TINE AND CAMEDONE IN THE PREVENTION AND TREATMENT OF EXPERIMENTAL ALPHA-VIRUS AND FLAVIVIRUS INFECTIONS

Antiviral activity of rybamidil (virasol) and interferon inducers rido stine and camedone developed in Russia and introduced in practical med icine has been studied in mice with experimentally induced arboviral i nfections, flavivirus (tick-borne encephalitis TEE, and yellow fever - YF) and alphavirus ones (Western and Eastern equine encephalomyelitis - WEE and EEE). Rybamidil injected subcutaneously proved to be ineffe ctive both for prevention and treatment of these infections. Early int erferon inducers ridostine and camedone (larifan) with a peak of inter feron production 4 hours after injection, when used in doses of 5 and 150 mg/kg, respectively, had a clear-cut prophylactic antiviral effect if injected 24 or 4 hours before infection. Ridostine had a distinct antiviral effect, providing up to 40% protection From TBE, YF, and WEE .