IMMUNIZING AND IMMUNOMODULATING ACTIVITY OF WILD MEASLES-VIRUS IN A FOCUS OF MEASLES INFECTION

The effect of a wild measles virus circulating in a childhood collecti ve body on the immune status of 80 children has been studied over time . Only using enzyme immunoassay was it possible to fully record and as sess the degree of booster effect of the virus on children in case of infection transmission. In 25% cases the increment of antibodies was a t the expense of specific IgM antibodies appearing in the sera of chil dren. By the end of the first month 60% of children developed a relati ve measles immunodepression. Analysis of the index of cell stimulation with phytohemagglutinin in the presence of suppressors enabled us to single out a group of children (30%) with weakly expressed suppressive factor. The observed phenomenon with a high degree of reliability may be used as an index of immune response development.