EFFECT OF THALAMIC-STIMULATION ON GAIT IN PARKINSON DISEASE

Objective: To assess the influence of ventral intermediate thalamic nu cleus stimulation on gait in idiopathic Parkinson disease. Design: Cli nical and physiological assessments were compared in patients with and without ventral intermediate thalamic nucleus stimulation. Setting: T he research clinic of a university department of gait analysis. Patien ts: Seven patients with idiopathic Parkinson disease who had long-term monopolar stimulation of the ventral intermediate thalamic nucleus to control a large-amplitude tremor. Main Outcome Measures: Gait kinemat ic parameters were automatically recorded using the Vicon optoelectric system for movement analysis. Measures of locomotor displacement (cad ence, walking speed, stride and step times, single and double support times, and stride and step lengths) were computed successively during 2 conditions: stimulation on and off. Traces of ankle joint position w ere also analyzed for the left and right lower limbs and for the affec ted and unaffected lower limbs. Results: NO difference in mean values was observed between the 2 conditions. Conclusion: This study seems to confirm that ventral intermediate thalamic nucleus stimulation, effec tive in reducing tremor, does not modify gait parameters in idiopathic Parkinson disease.