Opinions among national experts vary regarding the best treatment for
organ-confined prostate cancer, and the medical literature offers litt
le evidence to support one option over another. For patients 70 years
of age or younger who have a low Gleason score and a low prostate-spec
ific antigen level, surgery is the preferred treatment; however, radia
tion therapy may be an almost equivalent second choice, depending on t
he patient's concerns about preserving potency. For patients over age
70, radiation therapy is preferred, and the approach used may vary amo
ng medical centers. For the hypothetical 70-year-old patient described
in this article, the optimal treatment is controversial. Consideratio
ns include the expertise of the physicians involved and the patient's
willingness to tolerate unpleasant side effects, Fortunately, long-ter
m control is highly likely with any of the available treatments.