Background: Some patients with reflux esophagitis have solitary ulcers
in the distal esophagus. This study was undertaken to characterize fu
rther the radiographic features of these ulcers and to determine wheth
er or not they have a predisposition to develop on the posterior esoph
ageal wall. Methods: Radiologic files and teaching files at our univer
sity hospital and affiliated Veterans Administration hospital revealed
29 patients with solitary reflux-induced ulcers. The radiographs were
reviewed retrospectively to determine the size and location of the ul
cers as well as the presence or absence of other findings. Results: Tw
enty ulcers (69%) were located on the posterior wall, five (17%) on th
e left or right lateral wall, and four (14%) on the anterior wall. All
but two ulcers were located 1-4 cm from the gastroesophageal junction
. All of the ulcers were less than 10 mm in width and 5 mm in depth. O
ther associated findings included hiatal hernias in 11 patients (38%),
mucosal nodularity or granularity in 12 (41%), one or more tiny satel
lite ulcers in three (10%), esophageal intramural pseudodiverticula in
three (10%), an inflammatory esophagogastric polyp in one (3%), and s
carring or stricture formation in 12 (41%). Conclusion: Our findings s
uggest that solitary reflux-induced ulcers tend to occur on the poster
ior wall of the distal esophagus near the gastroesophageal junction, p
roducing characteristic radiographic findings. We postulate that affec
ted individuals sleep primarily in the supine position, so that reflux
ed acid pools on the dependent or posterior esophageal wall, causing m
aximal injury in this location.