Xl. Wang et al., REGENERATION OF RAT CORNEAL EPITHELIUM IS DELAYED BY THE INHIBITORY EPIDERMAL PENTAPEPTIDE (EPP), Acta ophthalmologica Scandinavica, 74(4), 1996, pp. 361-363
The effect of the inhibitory epidermal pentapeptide (EPP) on regenerat
ion of rat corneal epithelium was studied over a 24-h period after rem
oval of the central part of the corneal epithelium by means of n-hepta
nol and scraping. Both unphosphorylated and phosphorylated EPP inhibit
ed the mitotic rate and the formation of new cells to the same extent.
Thus, the mitosis inhibitor that originally was isolated from mouse e
pidermis, acts even on the ectodermally derived corneal epithelial cel
ls.