REGENERATION OF RAT CORNEAL EPITHELIUM IS DELAYED BY THE INHIBITORY EPIDERMAL PENTAPEPTIDE (EPP)

Authors
WANG XL ELGJO K HAASKJOLD E
Citation
Xl. Wang et al., REGENERATION OF RAT CORNEAL EPITHELIUM IS DELAYED BY THE INHIBITORY EPIDERMAL PENTAPEPTIDE (EPP), Acta ophthalmologica Scandinavica, 74(4), 1996, pp. 361-363
Citations number
20
Categorie Soggetti
Ophthalmology
Journal title
Acta ophthalmologica Scandinavica → ACNP
ISSN journal
13953907
Volume
74
Issue
4
Year of publication
1996
Pages
361 - 363
Database
ISI
SICI code
1395-3907(1996)74:4<361:RORCEI>2.0.ZU;2-3
Abstract
The effect of the inhibitory epidermal pentapeptide (EPP) on regenerat ion of rat corneal epithelium was studied over a 24-h period after rem oval of the central part of the corneal epithelium by means of n-hepta nol and scraping. Both unphosphorylated and phosphorylated EPP inhibit ed the mitotic rate and the formation of new cells to the same extent. Thus, the mitosis inhibitor that originally was isolated from mouse e pidermis, acts even on the ectodermally derived corneal epithelial cel ls.