Merck KGaA are shown in this profile to be filing pharmaceutical paten
t applications steadily, concentrating on cardiovascular and blood clo
tting therapies. A large team previously producing angiotensin II anta
gonists is now turning its attention to Na+/H+ exchange inhibitors; an
other is exploring cellular adhesion inhibitors. Few of these patentin
g initiatives have yet shown up in the company's development portfolio
. Unlike many companies, Merck KGaA does not routinely use the PCT mec
hanism to protect major inventions.