ANTI-IRS-1 MONOCLONAL-ANTIBODY, 6G5, CROSS-REACTS TO IRS-2

We previously reported the production of anti-IRS-l monoclonal antibod ies against human IRS-1 C-terminal portion, One of anti IRS-1 monoclon al antibodies, 6G5, was found to immunologically cross-react with IRS- 2, which has been reported recently. The data presented here provide i nformation arising from the use of the anti-IRS-1 MAb, 6G5; this MAb w as found to be a useful reagent in studying the functional role of IRS s in the insulin-signaling system.