NEUTROPHIL ADHESION MOLECULE EXPRESSION AND RESPONSE TO STIMULATION WITH BACTERIAL WALL PRODUCTS IN HUMANS IS UNAFFECTED BY PARENTERAL-NUTRITION

1. Total parenteral nutrition is associated with a high incidence of s eptic complications, This may be partly due to neutrophil dysfunction induced by the parenteral nutrition. 2. Neutrophil adhesion molecule e xpression and the expression of CD11b in response to stimulation with formylmethionyl-leucyl-phenylalanine and lipopolysaccharide were deter mined before and after 24 h of lipid-containing parenteral nutrition, Eighteen adult patients referred for parenteral nutrition were studied . 3. There was no change in the expression of neutrophil L-selectin (C D62L), CD11a, CD11b, CD11c or CD15. Neutrophil response to stimulation with formylmethionyl-leucyl-phenylalanine and lipopolysaccharide as d etermined by CD11b expression was unaffected by parenteral nutrition. 4. This study has shown no evidence of parenteral nutrition-induced ne utrophil dysfunction.