CANINE LYMPHOMATOID GRANULOMATOSIS - AN IMMUNOPHENOTYPIC ANALYSIS OF 3 CASES

Three dogs had a history of multiple progressive lesions affecting the skin, subcutis or skeletal muscles. The lesions developed over a peri od of several months, and each case demonstrated late cardiopulmonary complications. Post-mortem examination revealed multicentric, angio-de structive, lymphohistiocytic, proliferative lesions typical of the rar e disorder lymphomatoid granulomatosis. Immunohistochemical examinatio n demonstrated variable CD3 antigen expression by the atypical cell po pulation in two of the three cases. This provides the first evidence t hat canine lymphomatoid granulomatosis may be a form of atypical T-cel l lymphoma similar to the comparable disorder that occurs in man. (C) 1996 W.B. Saunders Company Limited