CALCULATION OF ENANTIOMER RATIO AND EQUILIBRIUM-CONSTANTS IN BIOCATALYTIC PING-PONG BI-BI RESOLUTIONS

Authors
ANTHONSEN HW HOFF BH ANTHONSEN T
Citation
Hw. Anthonsen et al., CALCULATION OF ENANTIOMER RATIO AND EQUILIBRIUM-CONSTANTS IN BIOCATALYTIC PING-PONG BI-BI RESOLUTIONS, Tetrahedron : asymmetry, 7(9), 1996, pp. 2633-2638
Citations number
7
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
7
Issue
9
Year of publication
1996
Pages
2633 - 2638
Database
ISI
SICI code
0957-4166(1996)7:9<2633:COERAE>2.0.ZU;2-K
Abstract
A computer program for the determination of kinetic and thermodynamic parameters in biocatalytic ping-pong bi-bi resolutions has been develo ped. The program uses enantiomeric excesses of both product (ee(p)) an d remaining substrate (ee(s)) measured at more than one conversion(xi) , and determines both the equilibrium constant K-eq, the enantiomer ra tio E and the selectivity factor alpha. The program has been tested fo r transesterification of 1-phenoxy-2-propanol using different excesses of acyl donor. Copyright (C) 1996 Elsevier Science Ltd