BETA-BUTYROLACTONE AS A CHIRAL BUILDING-BLOCK IN ORGANIC-SYNTHESIS - A CONVENIENT SYNTHESIS OF MK-0507 KETO SULFONE

Authors
TEMPKIN O BLACKLOCK TJ BURKE JA ANASTASIA M
Citation
O. Tempkin et al., BETA-BUTYROLACTONE AS A CHIRAL BUILDING-BLOCK IN ORGANIC-SYNTHESIS - A CONVENIENT SYNTHESIS OF MK-0507 KETO SULFONE, Tetrahedron : asymmetry, 7(9), 1996, pp. 2721-2724
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
7
Issue
9
Year of publication
1996
Pages
2721 - 2724
Database
ISI
SICI code
0957-4166(1996)7:9<2721:BAACBI>2.0.ZU;2-T
Abstract
The nucleophilic ring opening of (R)-beta-butyrolactone 2 with 2-thiop henethiolate is the key step in a straightforward stereospecific synth esis of keto sulfone 1, a precursor to carbonic anhydrase inhibitor MK -0507. Copyright (C) 1996 Elsevier Science Ltd