THE SYNTHESIS AND HIGH-RESOLUTION NMR-SPECTROSCOPY OF ETHYL AMINO)PHENYL]BUTANOYL)-L-SERYL-S-BENZYL-L-CYSTEINE - A CHELATE-CHLORAMBUCIL COMPLEX FOR USE AS A LIGAND FOR TC-99M RADIO-IMAGING

Authors
BELL RA HUGHES DW LOCK CJL VALLIANT JF
Citation
Ra. Bell et al., THE SYNTHESIS AND HIGH-RESOLUTION NMR-SPECTROSCOPY OF ETHYL AMINO)PHENYL]BUTANOYL)-L-SERYL-S-BENZYL-L-CYSTEINE - A CHELATE-CHLORAMBUCIL COMPLEX FOR USE AS A LIGAND FOR TC-99M RADIO-IMAGING, Canadian journal of chemistry, 74(8), 1996, pp. 1503-1511
Citations number
21
Categorie Soggetti
Chemistry
Journal title
Canadian journal of chemistry → ACNP
ISSN journal
00084042
Volume
74
Issue
8
Year of publication
1996
Pages
1503 - 1511
Database
ISI
SICI code
0008-4042(1996)74:8<1503:TSAHNO>2.0.ZU;2-6
Abstract
A potential agent for the imaging of tumours has been synthesized from the antineoplastic agent chlorambucil. Standard peptide coupling tech niques were used to synthesize a tripeptide covalently coupled to chlo rambucil in 10 steps. The final product was characterized by high-reso lution NMR spectroscopy.