SARCOGLANE, A NEW CYTOTOXIC DITERPENE FROM SARCOPHYTON GLAUCUM

Authors
FRIDKOVSKY E RUDI A BENAYAHU Y KASHMAN Y SCHLEYER M
Citation
E. Fridkovsky et al., SARCOGLANE, A NEW CYTOTOXIC DITERPENE FROM SARCOPHYTON GLAUCUM, Tetrahedron letters, 37(38), 1996, pp. 6909-6910
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
38
Year of publication
1996
Pages
6909 - 6910
Database
ISI
SICI code
0040-4039(1996)37:38<6909:SANCDF>2.0.ZU;2-G
Abstract
Sarcoglane (1) a new tricyclo[7,5,0(10,14)]tetradecane diterpenoid has been isolated from the Indo-Pacific soft coral Sarcophyton glaucum. T he structure of compound 1, which is cytotoxic to fertilized sea urchi n eggs, was defined by spectral methods and mainly 1D and 2D NMR exper iments. Sarcoglane possesses an unprecedented tricyclic carbon skeleto n, biogenetically, closely related to the cembrane and xeniaphyllane d iterpenoids. Copyright (C) 1996 Elsevier Science Ltd