4-CYANO-2-BUTENYL GROUP - A NEW-TYPE OF PROTECTING GROUP IN OLIGONUCLEOTIDE SYNTHESIS VIA PHOSPHORAMIDITE APPROACH

Authors
RAVIKUMAR VT CHERUVALLATH ZS COLE DL
Citation
Vt. Ravikumar et al., 4-CYANO-2-BUTENYL GROUP - A NEW-TYPE OF PROTECTING GROUP IN OLIGONUCLEOTIDE SYNTHESIS VIA PHOSPHORAMIDITE APPROACH, Tetrahedron letters, 37(37), 1996, pp. 6643-6646
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
37
Year of publication
1996
Pages
6643 - 6646
Database
ISI
SICI code
0040-4039(1996)37:37<6643:4G-ANO>2.0.ZU;2-F
Abstract
4-Cyano-2-butenyl (CB) is a new type of protecting group for the inter nucleotidic bonds in the synthesis of oligodeoxyribonucleotides by the phosphoramidite approach. This group is stable to acidic conditions a nd can be removed under mild conditions by a delta-elimination pathway using aqueous ammonium hydroxide. Copyright (C) 1996 Elsevier Science Ltd