PYRIDINE HYDROCHLORIDE - A NEW REAGENT FOR THE SYNTHESIS OF O-CHLORO HYDROXY DERIVATIVES IN PYRIDINE AND QUINOLINE SERIES

Citation
F. Mongin et al., PYRIDINE HYDROCHLORIDE - A NEW REAGENT FOR THE SYNTHESIS OF O-CHLORO HYDROXY DERIVATIVES IN PYRIDINE AND QUINOLINE SERIES, Tetrahedron letters, 37(37), 1996, pp. 6695-6698
Citations number
28
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
ISSN journal
00404039
Volume
37
Issue
37
Year of publication
1996
Pages
6695 - 6698
Database
ISI
SICI code
0040-4039(1996)37:37<6695:PH-ANR>2.0.ZU;2-2
Abstract
Pyridine hydrochloride has been widely used in the cleavage of ethers. It is shown herein that this reagent is also efficient for the synthe sis of chloro compounds starting from the corresponding bromo derivati ves in pi-deficient series such as pyridine and quinoline. Thus, for e xample, 7-bromo-8-hydroxyquinoline was almost quantitatively converted into 7-chloro-8-hydroxyquinoline. The scope of the reaction has been studied. Copyright (C) 1996 Published by Elsevier Science Ltd