INCORPORATION OF C-ALPHA-METHYL AMINO-ACIDS BY SOLID-PHASE PEPTIDE-SYNTHESIS IN A PEPTIDE SEQUENCE

Authors
BRUNISSEN A AYOUB M LAVIELLE S
Citation
A. Brunissen et al., INCORPORATION OF C-ALPHA-METHYL AMINO-ACIDS BY SOLID-PHASE PEPTIDE-SYNTHESIS IN A PEPTIDE SEQUENCE, Tetrahedron letters, 37(37), 1996, pp. 6713-6716
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
37
Year of publication
1996
Pages
6713 - 6716
Database
ISI
SICI code
0040-4039(1996)37:37<6713:IOCABS>2.0.ZU;2-9
Abstract
(S)-alpha Methylmethionine, (S)-alpha Methylleucine, 2-aminoisobutyric acid and (S)-alpha Methylphenylalanine have been incorporated by soli d phase peptide strategy in a peptide sequence. The coupling reactions of these Boc-alpha Me amino acids and of the following residue in the sequence were readily achieved after silylation with chlorotrimethyls ilane of the amine function on the resin. Copyright (C) 1996 Elsevier Science Ltd