ISOLATION AND STEREOSTRUCTURE OF AURILIDE, A NOVEL CYCLODEPSIPEPTIDE FROM THE JAPANESE SEA HARE DOLABELLA-AURICULARIA

Authors
SUENAGA K MUTOU T SHIBATA T ITOH T KIGOSHI H YAMADA K
Citation
K. Suenaga et al., ISOLATION AND STEREOSTRUCTURE OF AURILIDE, A NOVEL CYCLODEPSIPEPTIDE FROM THE JAPANESE SEA HARE DOLABELLA-AURICULARIA, Tetrahedron letters, 37(37), 1996, pp. 6771-6774
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
37
Year of publication
1996
Pages
6771 - 6774
Database
ISI
SICI code
0040-4039(1996)37:37<6771:IASOAA>2.0.ZU;2-W
Abstract
Aurilide (1), a new 26-membered cyclodepsipeptide, has been isolated f rom the Japanese sea hare Dolabella auricularia. The gross structure o f 1 was established by spectroscopic analysis. The absolute stereostru cture of 1 was determined by HPLC analysis of amino acid components an d isoleucic acid obtained from acidic hydrolysis of 1 and by the enant ioselective synthesis of the tris(p-bromobenzoate) 3 derived from the dihydroxy acid moiety. Copyright (C) 1996 Elsevier Science Ltd