QUINOLONE ANTIBIOTICS - STUDY OF REACTIVITY AND IMPURITY PROFILE OF PIPERAZINE WITH CHLORO-FLUORO-QUINOLONE CARBOXYLIC-ACID IN AQUEOUS-MEDIUM

Authors
KALKOTE UR SATHE VT KHARUL RK CHAVAN SP RAVINDRANATHAN T
Citation
Ur. Kalkote et al., QUINOLONE ANTIBIOTICS - STUDY OF REACTIVITY AND IMPURITY PROFILE OF PIPERAZINE WITH CHLORO-FLUORO-QUINOLONE CARBOXYLIC-ACID IN AQUEOUS-MEDIUM, Tetrahedron letters, 37(37), 1996, pp. 6785-6786
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
37
Year of publication
1996
Pages
6785 - 6786
Database
ISI
SICI code
0040-4039(1996)37:37<6785:QA-SOR>2.0.ZU;2-6
Abstract
The reaction of cyclopropyl-6-fluoro-4-oxo-1,2-dihydroquinoline-3- car boxylic acid with piperazine in water was studied. The product ciprofl oxacin was isolated and the impurity formed in the reaction was isolat ed and characterized as iperazinyl-4-oxo-1,2-dihydroquinoline-3-carbox ylic acid. Similarly norfloxacin was also synthesised. Copyright (C) 1 996 Published by Elsevier Science Ltd