A NEW SOLID-PHASE ASSAY SYSTEM USING MAGNETIC FORCE ON BLOOD-GROUP SEROLOGY

A new solid-phase assay system has been developed for the detection of irregular antibodies in plasma and serum specimens. By means of a mag netic indicator cell, we have established a sensitive and easy-to-hand le antihuman globulin (AHG) test involving magnetic-mixed passive hema gglutination (M-MPHA). Comparative studies of M-MPHA with conventional AHG tests demonstrated that this is sufficiently sensitive and specif ic to detect irregular antibodies to red blood cells. Elimination of c entrifugation in this test seems to open the way toward new standardiz ation of solid-phase systems.