GASTRIN-LEVELS IN MOTHERS AND NEONATES AT DELIVERY IN VARIOUS PERINATAL CONDITIONS

Background. This study was designed to assess the variations of gastri n (Ga) serum levels in mothers and newborns at birth in some perinatal disorders. Materials and methods. Ga levels were measured by RIA in m aternal serum, amniotic fluid and cord sera of newborns in 55 cases wi th the following conditions: normal pregnancy and eutocic vaginal deli very (n=8), repeat cesarean section (n=10): and cardiatogographic regi ster suggestive of fetal compromise (n=15), cephalopelvic disproportio n (n=8), preeclampsia (n=7) and postdate pregnancy (n=7). Statistical analysis was performed by Mann-Whitney U test. Results. Ga levels in c ord sera of newborn and amniotic fluid in normal pregnancy and eutocic delivery were significantly higher (p<0.02 and p<0.01, respectively) than those found in patients with repeat cesarean operation. Serum Ga concentrations in women with postterm pregnancy were significantly hig her (p<0.02) than in women with prior cesarean section. Ga levels in a mniotic fluid samples in the presence of suspected fetal compromise an d postdate pregnancy were significantly higher (p<0.001) than those ob served in women who had repeal cesarean operation. Conclusion. Vaginal delivery and perinatal pathology may induce hypergastrinemia in both mother and neonate at birth.