TEC PROTEIN-TYROSINE KINASE IS INVOLVED IN THE SIGNALING MECHANISM OFGRANULOCYTE-COLONY-STIMULATING FACTOR-RECEPTOR

Granulocyte colony-stimulating factor (G-CSF) is a critical cytokine t o promote the growth, differentiation, and functional activation of my eloid cells. Despite its important roles, little is still understood h ow one cytokine can trigger such pleiotropic effects, By using mouse c ell lines which can grow or differentiate in response to G-CSF, we inv estigated whether Tec protein tyrosine kinase is involved in either of the signaling pathways, Interestingly, Tec is shown to be tyrosine ph osphorylated and activated by the G-CSF stimulation in both cell growt h and differentiation mechanisms, Vav is also shown to be associated w ith Tec and tyrosine phosphorylated in response to G-CSF, Tec is a goo d candidate for protein-tyrosine kinases involved in both growth and d ifferentiation mechanisms of myeloid cells.