CYTOGENETIC FINDINGS IN RENAL-CELL CARCINOMA

Cytogenetic characterization of 24 renal cell carcinomas (RCCs) was pe rformed. The various RCC subtypes included 8 chromophobe RCCs, 12 nonp apillary RCCs, and 4 papillary RCCs. Loss of chromosomes 1, 2, 6, 10, and 17 were observed in 5 of 8 chromophobe RCCs. Five of the 12 nonpap illary RCCs showed abnormalities involving chromosome 3. These were de letion of the 3p13 region, loss of the whole chromosome 3, and unbalan ced translocation resulting in a derivative. Of the 4 papillary RCCs, two showed trisomy 7 and 17 along with other abnormalities, one had tr isomy for chromosomes 7, 12, and 13, along with loss of chromosome #5 and Y chromosomes, and another papillary RCC revealed trisomy 15 and t risomy 17. These results further show that specific cytogenetic abnorm alities are associated with various subtypes of RCCs. Copyright (C) 19 96 by W.B. Saunders Company