POLYCYSTIC-OVARY-SYNDROME AND DIAZOXIDE - AN IN-VIVO STUDY

The suppression of hyperinsulinism with diazoxide (300 mg/d during 30 days) in a young woman with PCOS and hirsutism, hyperinsulinism and in sulinoresistance was followed by a modification of plasma androgens. T estosterone (T) and free testosterone (FT) were reduced after ten days and then increased but always remained below the baseline level. DHEA S had increased 200% by day 10, and 3 alpha-adiol G to three times its basal value by day 20. These modifications were constant during the t reatment. fT decrease was secondary to reduction of hyperinsulinism wh ich was followed by an increase of TeBG and a modest and transient red uction of androgen theca cells production. DHEAS increase was due to h yperinsulinism suppression which stimulated adrenal 17-20 lyase activi ty. 3 alpha-adiol G increase was concomittant, and can be considered a s an index of adrenal androgen secretion.