STRAIN DIFFERENCES OF LIVER ALDEHYDE OXIDASE ACTIVITY IN RATS

The present study demonstrated a significant variation of Liver aldehy de oxidase activity in twelve strains of rats. The highest activity wa s found with Sea:SD rats and the lowest one with WKA/Sea rats. When as sayed using benzaldehyde as a substrate, the difference in the activit y between the two strains was 63.5-fold. Little significant difference s in Km values of the enzyme were observed among several strains. On t he other hand, Western blot analysis for the enzyme suggested that the strains possess different quantities of the enzyme, which are roughly parallel to aldehyde oxidase activity observed in the strains.