R. Berger et al., TRANSLOCATION T(10-11) INVOLVING THE MLL GENE IN ACUTE MYELOID-LEUKEMIA - IMPORTANCE OF FLUORESCENCE IN-SITU HYBRIDIZATION (FISH) ANALYSIS, Annales de genetique, 39(3), 1996, pp. 147-151
Fluorescence in situ hybridization analysis in an infant with acute mo
nocytic leukemia revealed a complex translocation, t(10;11;4) (p12;q23
;q26), Southern blot analysis confirmed the existence of rearrangement
of the MLL gene. The frequent occurrence of complex translocations in
volving 10p12 and 11q23 is discussed in function of the opposite orien
tation of the AF10 and MLL genes on 10p and 11q. The importance of FIS
H analysis in t(10;11) is emphasized.