TRANSLOCATION T(10-11) INVOLVING THE MLL GENE IN ACUTE MYELOID-LEUKEMIA - IMPORTANCE OF FLUORESCENCE IN-SITU HYBRIDIZATION (FISH) ANALYSIS

Authors
BERGER R LECONIAT M FLEXOR MA LEBLANC T
Citation
R. Berger et al., TRANSLOCATION T(10-11) INVOLVING THE MLL GENE IN ACUTE MYELOID-LEUKEMIA - IMPORTANCE OF FLUORESCENCE IN-SITU HYBRIDIZATION (FISH) ANALYSIS, Annales de genetique, 39(3), 1996, pp. 147-151
Citations number
39
Categorie Soggetti
Genetics & Heredity
Journal title
Annales de genetique → ACNP
ISSN journal
00033995
Volume
39
Issue
3
Year of publication
1996
Pages
147 - 151
Database
ISI
SICI code
0003-3995(1996)39:3<147:TTITMG>2.0.ZU;2-Q
Abstract
Fluorescence in situ hybridization analysis in an infant with acute mo nocytic leukemia revealed a complex translocation, t(10;11;4) (p12;q23 ;q26), Southern blot analysis confirmed the existence of rearrangement of the MLL gene. The frequent occurrence of complex translocations in volving 10p12 and 11q23 is discussed in function of the opposite orien tation of the AF10 and MLL genes on 10p and 11q. The importance of FIS H analysis in t(10;11) is emphasized.