ATRIOVENTRICULAR-CONDUCTION DURING ADENOSINE-INDUCED HYPOTENSION IN DOGS ANESTHETIZED WITH SEVOFLURANE

Citation
R. Ishii et al., ATRIOVENTRICULAR-CONDUCTION DURING ADENOSINE-INDUCED HYPOTENSION IN DOGS ANESTHETIZED WITH SEVOFLURANE, British Journal of Anaesthesia, 77(3), 1996, pp. 393-398
Citations number
40
Categorie Soggetti
Anesthesiology
ISSN journal
00070912
Volume
77
Issue
3
Year of publication
1996
Pages
393 - 398
Database
ISI
SICI code
0007-0912(1996)77:3<393:ADAHID>2.0.ZU;2-3
Abstract
We have studied the effects of adenosine-induced hypotension on A-H in terval (atrioventricular (AV) nodal conduction time during sinus rhyth m), St-H interval (intra-atrial plus AV nodal conduction time during a trial pacing), H-V interval (His-Purkinje conduction time) and H-S int erval (total ventricular conduction time) by Hisbundle electrocardiogr aphy in addition to surface electrocardiogram during both sinus rhythm and atrial pacing in nine dogs anaesthetized with 1 MAC of sevofluran e. Stepwise increases in infusion rates of adenosine to 0.1, 0.3, 0.5 and 1.0 mg kg(-1) min(-1) produced a dose-related decrease in mean art erial pressure from 91 (6) to 38 (2) mm Hg. Adenosine significantly in creased the A-H interval at infusion rates of 0.5 mg kg(-1) min(-)1 an d above, and the St-H interval at 1.0 mg kg(-1) min(-1). The H-V and H -S intervals remained unchanged. Heart rate decreased significantly on ly at 1.0 mg kg(-1) min(-1) with a significant increase in the PR inte rval. Adenosine-induced hypotension did not have deleterious effects o n AV conduction times and the surface electrocardiogram in dogs anaest hetized with 1 MAC of sevoflurane. This may indicate that the effects of adenosine on AV conduction were small and therefore are unlikely to be a contraindication to the use of adenosine for inducing hypotensio n in patients with initially normal conduction during sevoflurane anae sthesia.