BACKGROUND. The relationship between obesity and increased risks of mo
rbidity and mortality is well established. Less is known about the imp
act of obesity on functional health status and subjective well-being.
METHODS. We examined health-related quality of life (HRQL), measured b
y the Medical Outcomes Study Short Form-36 Health Survey (SF-36), and
clinical characteristics of 312 consecutive persons seeking outpatient
treatment for obesity at a university-based weight management center,
SF-36 scores were adjusted for sociodemographic factors and various c
omorbidities, including depression, to better estimate the effect of o
besity on HRQL, Health-related quality of life of the obese patients w
as then compared with that of the general population and with a sample
of patients who have other chronic medical conditions. RESULTS. Compa
red with general population norms, participants who had a mean body-ma
ss index (BMI) of 38.1 reported significantly lower scores (ie,more im
pairment) on all eight quality-of-life domains, especially bodily pain
and vitality. The morbidly obese (mean BMI, 48.7) reported significan
tly worse physical, social, and role functioning, worse perceived gene
ral health, and greater bodily pain than did either the mildly (mean B
MI, 29.2) or moderately to severely obese (mean BMI, 34.5). The obese
also reported significantly greater disability due to bodily pain than
did patients with other chronic medical conditions. CONCLUSIONS. Obes
ity profoundly affects quality of life. Bodily pain is a prevalent pro
blem among obese persons seeking weight loss and may be an important c
onsideration in the treatment of this population.