Tab. Sanders et al., POSTPRANDIAL ACTIVATION OF COAGULANT FACTOR-VII BY LONG-CHAIN DIETARYFATTY-ACIDS, Thrombosis and haemostasis, 76(3), 1996, pp. 369-371
Factor VII coagulant activity (FVIIc) is associated with an increased
risk of fatal ischaemic heart disease (IHD). Several reports have sug
gested that dietary fat intake or hypertriglyceridaemia are associated
with elevated levels of FVII. This study demonstrates that an intake
of long-chain fatty acids sufficient to induce postprandial lipaemia i
n healthy subjects leads to a substantial elevation in both FVIIc and
the concentration of FVII circulating in the activated form. Such an i
ncrease in FVIIc could not be induced by medium-chain triglycerides. T
hese results suggest that the consumption of a sufficient amount of lo
ng-chain triglycerides to induce postprandial lipaemia induces the act
ivation of FVII.