EPR-SPIN TRAPPING KINETIC-STUDIES OF SUPEROXIDE RADICALS PRODUCED BY PHOTOSENSITIZED HYPOCRELLIN-A, A PHOTODYNAMIC THERAPEUTIC AGENT

Authors
ZANG LY SHI XL MISRA HP
Citation
Ly. Zang et al., EPR-SPIN TRAPPING KINETIC-STUDIES OF SUPEROXIDE RADICALS PRODUCED BY PHOTOSENSITIZED HYPOCRELLIN-A, A PHOTODYNAMIC THERAPEUTIC AGENT, Biochemistry and molecular biology international, 38(4), 1996, pp. 685-691
Citations number
11
Categorie Soggetti
Biology
Journal title
Biochemistry and molecular biology international → ACNP
ISSN journal
10399712
Volume
38
Issue
4
Year of publication
1996
Pages
685 - 691
Database
ISI
SICI code
1039-9712(1996)38:4<685:ETKOSR>2.0.ZU;2-Q
Abstract
Kinetics of superoxide radicals generation by a photodynamic therapeut ic agent, Hypocrellin A has been studied by EPR-spin trapping techniqu e. The rate constant (k(g)) for superoxide radicals generation by Hypo crellin A was found to be 5.0 x 10(-3) s(-1). The first-order rate con stant (k(1)) and the half-life time (t(0.5)) for DMPO-O-2(-) decay wer e 2.86 x 10(-3) s(-1) and 242.3 s, respectively. It appears that oxyra dicals, generated during the photodynamic process, may be associated w ith the treatment of various skin diseases by photodynamic therapy of Hypocrellin A.