Sc. Greaves et al., CURRENT INCIDENCE AND DETERMINANTS OF PERIOPERATIVE MYOCARDIAL-INFARCTION IN CORONARY-ARTERY SURGERY, The American heart journal, 132(3), 1996, pp. 572-578
Increasingly, patients undergoing coronary artery bypass grafting (CAB
G) are elders, have had previous CABG, and have poor left ventricular
function. To evaluate determinants of perioperative myocardial infarct
ion (PMI) after isolated CABG, 499 consecutive patients were reviewed.
Definite PMI (total peak creatine kinase [CK] >700 U/L, creatine kina
se MB [CK-MB] 230 ng/ml, and new pathologic electrocardiographic Q wav
es) occurred in 25 patients (5.0%) and probable PMI (total peak CK >70
0 U/L, CK-MB >30 ng/ml, and a new wall-motion abnormality) occurred in
10 (2.0%) patients. According to multivariate logistic regression ana
lysis, independent risk factors for definite or probable PMI (odds rat
ios; 95% confidence intervals) were emergency surgery (3.1; 1.1 to 8.4
; p = 0.003), aortic cross-clamp time >100 minutes (4.2; 1.6 to 11.2;
p = 0.004), myocardial infarction in the preceding week (2.6; 1.0 to 6
.4; p = 0.04), and previous revascularization (2.4; 1.1 to 5.2; p = 0.
02). In conclusion, both preoperative and intraoperative factors influ
ence the risk of PMI after CABG. Despite changes in the profile of pat
ients undergoing CABG, the incidence of PMI in this tertiary center is
comparable with that found in earlier series, probably because of imp
rovements in surgical techniques and postoperative care.