SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF A SERIES OF N,N-DIMETHYL-N-ALKYL-D-GLUCAMINIUM BROMIDES

Citation
F. Gregan et al., SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF A SERIES OF N,N-DIMETHYL-N-ALKYL-D-GLUCAMINIUM BROMIDES, Chemicke zvesti, 50(5), 1996, pp. 310-315
Citations number
14
Categorie Soggetti
Chemistry
Journal title
ISSN journal
03666352
Volume
50
Issue
5
Year of publication
1996
Pages
310 - 315
Database
ISI
SICI code
0366-6352(1996)50:5<310:SAAAOA>2.0.ZU;2-K
Abstract
N,N-Dimethyl-N-alkyl-D-glucaminium bromides, with the number of carbon atoms in the alkyl chain varying from 8 to 22, have been synthesized by an S-N reaction of N,N-dimethyl-D-glucamine with 1-bromoalkanes. Th e target compounds were characterized and their structure proved by NM R and IR spectroscopy. The effect on S. aureus, E. coli, and C. albica ns was also examined and the antimicrobial activity expressed by the m inimum inhibitory concentration (MIC). The structure-activity relation ship was evaluated by the QSAR method using the Kubinyi's bilinear mod el.