F. Gregan et al., SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF A SERIES OF N,N-DIMETHYL-N-ALKYL-D-GLUCAMINIUM BROMIDES, Chemicke zvesti, 50(5), 1996, pp. 310-315
N,N-Dimethyl-N-alkyl-D-glucaminium bromides, with the number of carbon
atoms in the alkyl chain varying from 8 to 22, have been synthesized
by an S-N reaction of N,N-dimethyl-D-glucamine with 1-bromoalkanes. Th
e target compounds were characterized and their structure proved by NM
R and IR spectroscopy. The effect on S. aureus, E. coli, and C. albica
ns was also examined and the antimicrobial activity expressed by the m
inimum inhibitory concentration (MIC). The structure-activity relation
ship was evaluated by the QSAR method using the Kubinyi's bilinear mod
el.