PERMEATION KINETICS OF DIMETHYL-SULFOXIDE IN ARTICULAR-CARTILAGE

Authors
MULDREW K SYKES B SCHACHAR N MCGANN LE
Citation
K. Muldrew et al., PERMEATION KINETICS OF DIMETHYL-SULFOXIDE IN ARTICULAR-CARTILAGE, Cryo-letters, 17(6), 1996, pp. 331-340
Citations number
11
Categorie Soggetti
Biology Miscellaneous",Physiology
Journal title
Cryo-letters → ACNP
ISSN journal
01432044
Volume
17
Issue
6
Year of publication
1996
Pages
331 - 340
Database
ISI
SICI code
0143-2044(1996)17:6<331:PKODIA>2.0.ZU;2-6
Abstract
H-1-NMR was used to monitor concentration of dimethyl sulfoxide in art icular cartilage on patellae from pigs as a function of time and tempe rature. The resulting diffusion coefficient was 1.12x10(-5).cm(2)/sec at 23 degrees C with an Arrhenius activation energy of 0.95 kcal/mol. Concentration profiles in cartilage of various thicknesses were calcul ated as a practical aid for the design of protocols to cryopreserve ar ticular cartilage.