A unique case of primary myxoid liposarcoma of the thigh, in which foc
al pleomorphic areas were present containing rhabdomyoblasts, is descr
ibed. Focal rhabdomyosarcoma in Liposarcoma has only rarely been repor
ted previously and only in dedifferentiated liposarcomas of the retrop
eritoneum. All but one have been recurrences with rhabdomyoblasts bein
g absent in the primary liposarcoma. As rhabdomyoblasts were only foca
lly present, the present case is regarded as liposarcoma with focal di
vergent rhabdomyoblastic differentiation rather than malignant mesench
ymoma.