A 69-year-old man with hypoxemic COPD underwent placement of a transtr
acheal oxygen (TTO) catheter, At 3 months, the catheter tract appeared
mature with minimal erythema and no evidence of infection at the cath
eter site. The patient and his spouse were taught to remove and reinse
rt the catheter but were told to delay beginning the procedure due to
erythema at the stoma site. Despite instructions not to remove the cat
heter for cleaning, the spouse removed the TTO catheter and attempted
to reinsert it using the flexible metal cleaning rod. Subsequently, th
e patient suffered an acute episode of subcutaneous air and hemodynami
c collapse resulting in death. Necropsy revealed a false catheter trac
t occluded by clotted blood and a defect in the platysma muscle where
oxygen had dissected into the mediastinum. The patient died due to pne
umomediastinum and cardiac tamponade.