INHIBITION OF HELICOBACTER-PYLORI UREASE ACTIVITY BY EBROTIDINE

Helicobacter pylori is considered a primary factor in the pathogenesis of gastric disease, and the successful mucosal colonization is linked to its urease activity. In this study, we assessed the effect of anti ulcer agent, ebrotidine, on the in vitro activity of H. pylori urease. The results of assays showed a dose-dependent inhibition of the ureas e activity. A maximum inhibition (77%) in H. pylori urease activity oc curred at 2.1 mu M ebrotidine. A known H-2-blocker, ranitidine, in a p arallel experiment gave a maximal inhibition of 73% at a considerably higher concentration (6.4 mu M). The results demonstrate that ebrotidi ne with its combined acid suppressant and anti-H. pylori activities of fers an excellent choice in the treatment of H. pylori associated gast ric disease.